Review





Similar Products

c 176  (MedChemExpress)
96
MedChemExpress c 176
SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
C 176, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/c 176/product/MedChemExpress
Average 96 stars, based on 1 article reviews
c 176 - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier
pass filter  (Mini-Circuits)
94
Mini-Circuits pass filter
SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
Pass Filter, supplied by Mini-Circuits, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/pass filter/product/Mini-Circuits
Average 94 stars, based on 1 article reviews
pass filter - by Bioz Stars, 2026-03
94/100 stars
  Buy from Supplier
sting inhibitor c 176  (MedChemExpress)
96
MedChemExpress sting inhibitor c 176
SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD <t>+C-176</t> group; &P < 0.05 versus OGD+JQ1 group.
Sting Inhibitor C 176, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sting inhibitor c 176/product/MedChemExpress
Average 96 stars, based on 1 article reviews
sting inhibitor c 176 - by Bioz Stars, 2026-03
96/100 stars
  Buy from Supplier

Image Search Results


SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD +C-176 group; &P < 0.05 versus OGD+JQ1 group.

Journal: Drug Design, Development and Therapy

Article Title: (+)-JQ1 Upregulates SIRT3 to Suppress cGAS/STING Pathway-Mediated Neuronal Inflammation and Ferroptosis After Hypoxic-Ischemic Encephalopathy

doi: 10.2147/DDDT.S578815

Figure Lengend Snippet: SIRT3 Mediates the Protective Effects of JQ1 Against CGAS/STING Activation and Ferroptosis Following OGD. ( A ) Representative Western blot images of SIRT3, cGAS, and STING expression in HT22 cells. ( B ) Representative images of immunofluorescence staining for STING (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( C ) Representative images of immunofluorescence staining for cGAS (green) and DAPI (blue) in HT22 cells of each group. Scale bar = 25μm. ( D – G ) Representative Western blot images and quantification of SLC3A2, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. ( H – K ) Representative Western blot images and quantification of STING, SLC7A11, and GPX4 expression (normalized to β-Actin) in HT22 cells. Data are expressed as mean ± SD independent replicates: ns: not significant; ###P < 0.001 versus Control group; *P < 0.05, **P < 0.01, ***P < 0.001 versus OGD+JQ1+si-NC group; @P < 0.05, @@P < 0.01, @@@P < 0.001 versus OGD +C-176 group; &P < 0.05 versus OGD+JQ1 group.

Article Snippet: To inhibit STING, the cells were pre-stimulated with 1 μM C-176 (HY-112906, MedChemExpress, China) before cultured in hypoxic condition.

Techniques: Activation Assay, Western Blot, Expressing, Immunofluorescence, Staining, Control